Hollywood’s hangover is a lot bigger the second time around.

“The Hangover Part II” hauled in $86.5 million in its first weekend, putting Hollywood on course to set a new revenue record for the long Memorial Day weekend, according to studio estimates Sunday.

From Friday to Sunday, Hollywood’s domestic take totaled about $220 million. Once Monday’s receipts are counted, the industry should finish the four-day weekend with around $270 million, easily topping the $254.6 million Memorial Day record set in 2007, said Paul Dergarabedian, box-office analyst for Hollywood.com.

“The Hangover” sequel did nearly twice the business of the original blockbuster comedy in its $45 million opening weekend two years ago.

In its first four days since opening Thursday, the Warner Bros. sequel has taken in $118.1 million and is on track to finish the long Memorial Day weekend with about $140 million in the bank.

The first “Hangover” did not hit the $100 million mark until its second weekend. The movie went on to gross $277 million domestically.

“The Hangover Part II” reunites stars Bradley Cooper, Ed Helms and Zach Galifianakis as they awake in another haze and attempt to piece together the mayhem of their drunken night in Bangkok.

That gave the film a whopping average of $88,080 a theater, compared to a $23,923 average in 3,615 cinemas for “The Hangover Part II.”