Last year, MTV hosted the Video Music Awards in its birth place, New York City. But this year, it’s time for a change of scenery, and the VMAs will take it to the West Coast when the show airs live from Los Angeles on September 12.

And after 27 years, you know that when you tune in, you’ll be treated to an unforgettable awards ceremony starring the biggest A-list presenters and rockin’ performances from your favorite artists, plus plenty of Moonmen to give away.

So who’s going to take us on an unforgettable ride through this star-studded night? Comedienne Chelsea Handler is confirmed to host the 2010 VMAs! Don’t worry, she’s no stranger to hosting TV programs – she’s been the wisecracking anchor on her late-night show “Chelsea Lately” since 2007. Known for her tongue-in-cheek commentary, Chelsea’s honest and witty banter won her the honor of being the second woman to grace the VMA stage as a solitary host, followed by Roseanne Barr in 1994. Whew, it’s a been awhile. Let’s hear it for the girls!

And of course, when it comes to the VMAs, expect the unexpected. Who knows what kind of award show memories the 2010 VMAs will chalk up? But if years past are any indication, the possibilities are endless. Who can forget just last year when Kanye West hijacked Taylor Swift’s acceptance speech?!

So who will dominate with the most Moonmen at this year’s show? Be sure to tune into the 2010 show to find out. And don’t forget that while voting for most categories is now closed, you can still vote for Best New Artist, which will remain open into the show. Stay tuned for more details and be sure to take your front-row seat for the action, live, Sunday, September 12, at 9/8c.-MTV