The Young Money crew is packing their Louis Vuitton bags and heading south of the border. Hip-hop’s first family will descend on Acapulco, Mexico, for one big spring break party later this month.

Drake and Nicki Minaj will help headline MTV Spring Break 2010, along with other members of the YM supergroup, performing their No. 2 single in the country “BedRock.” Drizzy will get the crowd hyped with “Over,” the first offering from his debut album Thank Me Later, while Young Money’s First Lady ambushes the stage with the first live performance of her new single “Massive Attack,” produced by Sean Garrett and Alex Da Kid.

Hip-hop’s Barbie won’t only pop up during Young Money’s set. Minaj will storm the sandy shores of Mexico with Ludacris for their collaboration “My Chick Bad” from Luda’s Battle of the Sexes album.

The ATL rapper will have spring breakers asking “how low can you go” when he performs the remix to his smash hit with Pitbull, who will get the party started with some of his own crowd pleasers.

If that wasn’t enough, the ladies will break into a sweat once Trey Songz serenades them with material from his Ready album, including the Top 10 hit “Say Aah,” while his labelmate, hip-hop freshman B.o.B, crashes la fiesta with his breakout single “Nothin’ on You” featuring Bruno Mars.

MTV will premiere a performance from a different artist each night at 8 p.m. from March 22-26.